Dr Tshepo Motsepe is the wife of South African President Cyril Ramaphosa and serves as the First Lady of South Africa. The couple has been married since 1996. [1, 2]Current Marriage & First LadyDr Tshepo Motsepe: A prominent South African physician and businesswoman. She holds a Master of Public Health from the Harvard School of Public Health. [1]Prominent In-laws: Through Dr Motsepe, Ramaphosa is connected to one of South Africa’s wealthiest families. Her brother is the mining billionaire Patrice Motsepe, and her sister is the businesswoman Bridgette Radebe. [1, 2]ChildrenPresident Ramaphosa has five children from his marriages: [1]Andile Ramaphosa: His eldest son, an entrepreneur who famously married Bridget Birungi, the niece of former Ugandan Prime Minister Amama Mbabazi.Tumelo Ramaphosa: A prominent businessman and CEO of Studex Meat.Keneilwe Ramaphosa: An architect who earned her Master’s degree from Columbia University and works internationally.Nakisani Ramaphosa: Works in the real estate sector.Mashudu Ramaphosa: His youngest daughter, who mostly stays out of the public spotlight. [1, 2, 3, 4, 5]Previous MarriagesBefore marrying Dr Motsepe, Ramaphosa was married twice: [1, 2, 3]Hope Ramaphosa (Mudau): Married from 1978 until their divorce in 1989. They share their eldest son, Andile.Nomazizi Mtshotshisa: Married in 1991, they divorced in 1993. She was a well-known businesswoman who passed away in 2008. [1, 2, 3, 4, 5]Parents and Early RootsParents: He was born to Samuel and Erdmuth Ramaphosa. His father was a policeman.Origins: He grew up in a Venda-speaking family in Western Native Township, before his family was forcefully relocated to Soweto in 1962